BIOCHEMISTRY OF CANCER
11:115:421
(Monday/Thursday 12:35-1:50 p.m.)

Lori White, Ph.D.                              Dr. Harinder Dani, Ph.D.

lawhite@aesop.rutgers.edu                harryd8@yahoo.com

732-932-9763 X128                         732- 447-3684

 

DATE

TOPIC

 

READING

ASSIGNMENT

 

 

 

 

 

1-19 (Th)

Introduction

 

 

 

1-23(M)

Cancer Etiology: Chemicals and Radiation

HD

Ch.  5, 6

Quiz 1

1-26 (Th)

B.Elo

S. Jafary

D. Smilovitch

L. Rakhlin

 

 

 

1-30 (M)

 Cancer Etiology:      Infectious Agents and Heredity                                                                 

HD

Ch. 7, 8

Quiz 2

2- 2(Th)

V. LaPrete

S. Izadmehr

F. Naik

S. Tormasi

 

 

 

2-6 (M)

DNA damage and repair

LW

Ch. 2

Quiz 3

2-9 (Th)

C. Benson

K. Hess

S. Vaspory

R. Prates

 

 

 

2-13 (M)

Cell cycle & Apoptosis

LW

Handout from DeVita et al (2005)

Quiz 4

2-16 (Th)

D. Kagan

P. Lizano

B. Snaguski

V. Shah

 

 

 

2-20 (M)

Oncogenes & Tumor Suppressors

HD

Ch. 9, 10

Quiz 5

2-23 (Th)

S. Gillberg

M. Dizon

K. Singh

S. Vaidya

 

 

 

2-27 (M)

Metastasis and angiogenesis

LW

Ch. 3

Quiz 6

3-2 (Th)

D. Eisenhour

C. Diaz

S. Veerasammy

N. Patel

 

 

 

3-6 (M)

Cancer and the immune system

HD

Handout  from  Devita et al (2005)

Quiz 7

3-9 (Th)

Midterm EXAM

 

 

 

3-20 (M)

Cancer chemotherapy

HD

Ch. 11

Quiz 8

3-23 (Th)

C. Molina

X. Dai

N. Zygnerski

Y. Pennesi

 

 

 

3-27 (M)

M. Alter

A. DiCicco

D. Shah

A. Zakian

 

 

 

3-30 (Th)

Nutrition in cancer

HD

Ch. 12

Quiz 9

4-3 (M)

Mohamid Rafi

 

 

Specific Aims for Final Paper

4-6 (Th)

Single Nucleotide Polymorphisms

LW

 

 

4-10 (M)

James Goydos

 

 

 

4-13 (Th)

Use of animal models

LW

 

 

4-17 (M)

Suzie Chen

 

 

 

4-20 (Th)

Clinical trials

 

 

 

4-24 (M)

Eric Rubin (?)

 

 

 

4-27 (Th)

Final EXAM

 

 

 

5-1 (M)

Last Class

 

 

Grant Proposals Due

 

Recommended Book:  Principles of Cancer Biology, Kleinsmith, (2005).

 

Goals of the Course:  This is a 3 credit course upper level Biochemistry elective.  The goals of this course are to introduce the

student to the basic concepts of the mechanisms of carcinogenesis and to begin applying these concepts to research problems.

 

Course Organization:  This course meets two times a week. On Monday, lectures will be given in 127 Hickman Hall. 

For Thursday classes, the students will be divided into two groups, one meeting in 127 Hickman Hall with Dr. Dani,

the other meeting in 325 Lipman Hall  with Dr. White.   During the Thursday class students will give oral presentations.

 

Student Requirements:  

Exams: There are two exams in this course, a midterm exam covering the first 7 weeks, and a non-cumulative final.

Exam will be primarily multiple choice and short answer. 

 

Quizzes: There will be short (>10 questions) quizzes at the beginning of every lecture based on the reading.

Oral presentation:  Each student will give an oral presentation based on a current scientific article related to the week’s topic.

Final Paper:  The final assignment will be to write a grant proposal focusing on the topics that we have covered in class. 

A detailed description of the format and expectations will be given to students following the midterm assignments.

 

Student performance in this course will be evaluated based on:

Quiz                                         (10%)

Individual presentation              (20%)

Midterm exam                          (25%)

Final Exam                               (15%)

Final report                              (30%)

 

Grades are based on the writing assignments and participation in class discussions. Students are expected to come to class

prepared for the class.  Cell phones and beepers must be turned off during class. 

Late papers will not be accepted unless the student makes prior arrangements with the professor.