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Department of Biochemistry and Microbiology
76 Lipman Drive
Room 218
New Brunswick, NJ 08901-8525
(732) 932-9763 x 218
Fax: (732) 932-8965
cooper@aesop.rutgers.edu
Home Page: aesop.rutgers.edu/~cooper
Professor
B.S. (Biology), College of William and Mary, 1973
M.S. (Marine Biology), Texas A&M University, 1976
Ph.D.(Animal Pathology), University of Rhode Island, 1979
M.S. (Industrial Toxicology), Thomas Jefferson University, 1981
Xenobiotic metabolism in aquatic animals
Studies are currently examining the effects of endocrine disrupting compounds on finish and bivalve mollusks. The compounds of current interest include dioxin-like compounds and phthalates. The model systems used for these studies include the Japanese Medaka, winter flounder and the American oyster. The research on the finish involves the development of multigenerational studies examining the effects at multiple levels of organization from biochemical to population endpoints. The studies on the American oyster are examining the effects on gonadal development and larval development. Both food web and physiological based pharmacokinetic models are also being developed to better predict chemical movement both in the environment as well as within the organism of concern. The overall research in the laboratory is centered around comparative toxicology.
Recent publications
Hillegass, J.M., Villano, C.M., Cooper, K.R. and White, L.A. 2007. Matrix metalloproteinase-13 (MMP-13) is required for zebrafish (Danio rerio) development and is a target for glucocorticoids. Tox. Sci. (accepted).
Domico, L. Yang I, Buckley B., Zeevalk, G.D. and Cooper, K.R. 2007. Measurement of the Mn/Zn-ethylene-bis-dithiocarbamate Mancozeb in biological matrixes and demonstration of uptake by neuronal cells. Tox. Sci. (submitted).
Domico, L. Cooper, K.R., Bernard, l.P. and Zeevalk, G. 2007. Reactive oxygen species generation by the ethylene-bis-diothiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology, doi:10.1016/j.neuro.2007.04.008.
Wintermyer M.L. and Cooper, K.R. 2007. The development of an aquatic bivalve model: Evaluating the toxic effects on gametogenesis following 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) exposure in the eastern oyster (Crassostria virginica). Aquatic Toxicology. 81, 10-26.Domico, L., Zeevalk, G., Bernard, L., and Cooper, K., 2006. Acute neurotoxic effects of Mancozeb and Maneb in mesencephalic neuronal cultures are associated with mitochondrial dysfunction. Journal of Neuroscience. 27, 816-825.
